反应详情

The mixture of [4-(3-{6-[(thiophen-3-ylmethyl)-amino]-pyridin-2-yl}-imidazo[1,2-a]pyrazin-8-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester (70 mg, 0.135 mmol) in ethanol (4 mL) and concentrated HCl (4 mL) was stirred at room temperature for 15 h. The reaction mixture was then concentrated under reduced pressure to give N-(3-{6-[(thiophen-3-ylmethyl)-amino]-pyridin-2-yl}-imidazo[1,2-a]pyrazin-8-yl)-cyclohexane-1,4-diamine; hydrochloride. (Yield 83 mg). 1HNMR (300 MHz, CD3OD): δ 8.06 (s, 1H), 7.94 (d, 1H, J=5.4 Hz), 7.87 (t, 1H, J=8.7 Hz), 7.39-7.34 (m, 2H), 7.16-7.03 (m, 4H), 4.62 (s, 2H), 3.98 (brs, 1H), 3.14 (brs, 1H), 2.14-2.09 (brs, 4H), 1.70-1.60 (m, 4H). LC-MS: [M+H]+ 420.

1. concentrationThe reaction mixture was then concentrated under reduced pressure