反应详情

温度

52 °C

4-Trifluoromethyl-6-(4-nitrophenyl)-2-(4-trifluoromethylphenyl)-pyrimidine. A solution of 4-trifluoromethyl-2-methylsulfanyl-6-(4-nitrophenyl)-pyrimidine (1.25 g, 4.0 mmol; prepared from 1-(4-nitrophenyl-4,4,4-trifluorobutane-1,3-dione according to Green et al. WO 200138311 A2), 4-trifluoromethylphenylboronic acid (0.95 g, 5.0 mmol), trifurylphosphine (140 mg, 0.60 mmol), and copper (II) 2-thiophenecarboxylate (1.05 g, 5.0 mmol) were combined in dry THF (25 mL) and heated to 52° C. The catalyst tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct (100 mg) was then added in three portions over 3 h, and the solution was then allowed to stir at 50° C. for 12 h. Concentration and chromatography (Biotage, 4:1 hexane/CH2Cl2) furnished the title compound (0.67 g, 41%) as a light yellow solid: mp 162° C.; 1H NMR (300 MHz, CDCl3) δ 8.75 (d, J=8 Hz, 2H), 8.41 (s, 4H), 8.03 (s, 1H), 7.80 (d, J=8 Hz, 2H); EIMS m/z 414.1 (M+H).

1. concentrationConcentration and chromatography (Biotage, 4:1 hexane/CH2Cl2)