Hydrochloric Acid → HCID 86666492, compound

HRID 1189699Notes

Reaction equation

HRID 1189699 reaction equation
[F:1][C:2]([F:47])([F:46])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:35]([N:36]2[CH2:41][CH2:40][CH:39]([C:42]([F:45])([F:44])[F:43])[CH2:38][CH2:37]2)=[CH:34][C:11]2[N:12]([CH3:33])[C:13]([NH:15][C:16]3[C:21]([Cl:22])=[CH:20][CH:19]=[C:18]([CH2:23][NH:24]C(OC(C)(C)C)=O)[C:17]=3[Cl:32])=[N:14][C:10]=2[CH:9]=1)=[O:7].Cl>C1COCC1>[F:46][C:2]([F:1])([F:47])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:35]([N:36]2[CH2:41][CH2:40][CH:39]([C:42]([F:45])([F:44])[F:43])[CH2:38][CH2:37]2)=[CH:34][C:11]2[N:12]([CH3:33])[C:13]([NH:15][C:16]3[C:21]([Cl:22])=[CH:20][CH:19]=[C:18]([CH2:23][NH2:24])[C:17]=3[Cl:32])=[N:14][C:10]=2[CH:9]=1)=[O:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86666491HCID 86666491, compound

Product 1

HCID 86666492HCID 86666492, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of N-(3,3,3-trifluoropropyl)-2-{2,6-dichloro-3-[(tert.-butoxycarbonylamino)-methyl]-phenylamino}-6-[4-trifluoromethyl-piperidinyl]-1-methyl-1H-benzimidazole-5-carboxylic acid amide (2.73 g, 3.8 mmol), 15 mL 6M aq HCl and 15 mL THF is stirred for 2 h, concentrated and the sub title compound is purified by chromatography (silica gel, DCM→DCM/10% EtOH+few drops of NH4OH). Yield: 2.3 g. Rf=0.27 (DCM/EtOH/NH4OH 90:10:1). MS m/z: 712 [M+H]+.

Workup

  1. concentrationconcentrated
  2. customthe sub title compound is purified by chromatography (silica gel, DCM→DCM/10% EtOH+few drops of NH4OH)

Sources & evidence

ORD record
ord-dae6808da3644f119cff65e28205b0ca
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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