反应详情

A mixture of tert-butyl-dimethyl-[2-methyl-2-(4-nitro-phenyl)-propoxy]-silane (as prepared in the previous step, 1.70 g, 5.49 mmol) and 10% Pd/C (850 mg, 50 wt %) in 30 mL of EtOAc was stirred at RT under H2 (balloon pressure) for 6 h. The Pd catalyst was removed by filtration on Celite and the filtrate was concentrated. The residue was purified by flash chromatography on silica gel (5-10% EtOAc/DCM) to give 1.43 g (93%) of the title compound as a light brown oil. Mass spectrum (ESI, m/z): Calcd. for C16H29NOSi, 280.2 (M+H). found 280.4.

1. customThe Pd catalyst was removed by filtration on Celite
2. concentrationthe filtrate was concentrated
3. customThe residue was purified by flash chromatography on silica gel (5-10% EtOAc/DCM)