反应详情

3-[(tert-butylamino)methyl]-4-(4-methylpiperazin-1-yl)aniline (60 mg, 0.22 mmol) and 4,7-dichloroquinoline (43 mg, 1 eq) were refluxed overnight in 10 mL of acetonitrile with 0.43 mL of HCl 1M. The reaction mixture was then evaporated and purified by preparative thin-layer chromatography (DCM/MeOH/NH4OH/18/210.1) to yield expected compound as a pale yellow solid (45 mg, 47% yield). m/z (ESI) 438.3 [M+H]+.

1. customThe reaction mixture was then evaporated
2. custompurified by preparative thin-layer chromatography (DCM/MeOH/NH4OH/18/210.1)