反应详情

[2-(4-Methylpiperazin-1-yl)-5-nitrophenyl]methanol prepared in step A of example 1 (1.00 g, 3.98 mmol) was hydrogenated using ammonium formate (2.51 g, 10 eq) and Pd/C (10% Pd, 0.43 mg, 0.1 eq) in 50 mL of EtOH. The mixture was stirred overnight at room temperature and then filtered through a celite pad. The filtrate was evaporated and the residue was dissolved in DCM and washed with an saturated aqueous solution of Na2CO3. The aqueous layer was extracted with DCM. The combined organic layers were dried over Na2SO4, filtered and evaporated to yield expected compound as a pale yellow oil (0.85 g, 97% yield).

1. filtrationfiltered through a celite pad
2. customThe filtrate was evaporated
3. dissolutionthe residue was dissolved in DCM
4. washwashed with an saturated aqueous solution of Na2CO3
5. extractionThe aqueous layer was extracted with DCM
6. dry with materialThe combined organic layers were dried over Na2SO4
7. filtrationfiltered
8. customevaporated