反应详情

1-methyl-4-[3-(4-methylpiperazin-1-yl)-5-nitrophenyl]piperazine (258 mg, 0.81 mmol) was hydrogenated using ammonium formate (0.51 g, 10 eq) and Pd/C (10% Pd, 85 mg, 0.1 eq) in 8 mL of EtOH. The mixture was stirred overnight at room temperature and then filtered through a celite pad. The filtrate was evaporated and the residue was dissolved in DCM and washed with a saturated aqueous solution of Na2CO3. The aqueous layer was extracted with DCM. The combined organic layers were dried over Na2SO4, filtered and evaporated to yield expected compound as a brown powder (212 mg, 90% yield). m/z (MALDI-TOF) 290.2 [M+H]+.

1. filtrationfiltered through a celite pad
2. customThe filtrate was evaporated
3. dissolutionthe residue was dissolved in DCM
4. washwashed with a saturated aqueous solution of Na2CO3
5. extractionThe aqueous layer was extracted with DCM
6. dry with materialThe combined organic layers were dried over Na2SO4
7. filtrationfiltered
8. customevaporated