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HRID1191853

反应详情

EQUATION

反应方程式

HRID 1191853 的结构方程式

REACTANTS

反应物

2
结构：C[C@@H](c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O
HCID59532385

(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one

C28H38BNO5

结构：Cn1cc(F)c(Br)cc1=O
HCID59635671

4-Bromo-5-fluoro-1-methylpyridin-2(1H)-one

C6H5BrFNO

PRODUCTS

生成物

1
结构：C[C@@H](c1ccc(-c2cc(=O)n(C)cc2F)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O
HCID59635727

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-[(S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl]-1,3-oxazinan-2-one and 4-bromo-5-fluoro-1-methyl-1H-pyridin-2-one following a procedure analogous to that described in Example 76. Mass spectrum (ESI+): m/z=479 [M+H]+. The compound that had been obtained as an oil crystallized on standing. The solid was dried at 80° C. under vacuum. Melting points: 120-125° C. with evolution of gas followed by recrystallization and melting at 183-184° C.

WORKUP

后处理

  1. customThe compound that had been obtained as an oil
  2. customcrystallized
  3. customThe solid was dried at 80° C. under vacuum
  4. custom120-125° C. with evolution of gas followed by recrystallization and melting at 183-184° C.