反应详情

The title compound was prepared in a manner analogous to Intermediate 2, substituting (1R,6S)-(3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester for 3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester and 4-chloro-2-trifluoromethyl-6-methyl-pyrimidine for 2-chloro-quinoxaline in Step A. MS (ESI) mass calcd. for C12H15F3N4, 272.27; m/z found 273.0 [M+H]+. 1H NMR (CDCl3): 6.29 (s, br, 1H), 6.13 (s, 1H), 4.52 (d, J=8.0, 1H), 4.08-3.94 (m, 1H), 3.87-3.75 (m, 1H), 3.64 (t, J=19.8, 1H), 3.39-3.26 (m, 1H), 3.11 (dd, J=14.2, 3.5, 1H), 3.00-2.77 (m, 2H), 2.38 (s, 3H), 2.22-2.07 (m, 1H), 1.92-1.79 (m, 1H).