反应详情

Benzyl 1-(2,6-dimethylpyrimidin-4-yl)piperidin-4-yl(methyl)carbamate (3.6 g, 10.169 mmol, 1.0 eq.) was dissolved in MeOH (40 ml) and degassed for 15 min with N2. Pd(OH)2 (800 mg) was then added, and hydrogenation was carried out for 4 hours at room temperature under balloon pressure. After monitoring by TLC, the reaction mixture was filtered over Celite and washed with methanol (100 ml). The filtrate was concentrated under reduced pressure and the crude product was used in the next stage without being purified further. Yield: 95% (2.12 g, 9.636 mmol)

1. customdegassed for 15 min with N2
2. additionPd(OH)2 (800 mg) was then added
3. filtrationthe reaction mixture was filtered over Celite
4. washwashed with methanol (100 ml)
5. concentrationThe filtrate was concentrated under reduced pressure
6. customwithout being purified further