Diethoxymethane → 4-Methyl-6-methylenandrost-4-ene-3,17-dione

HRID 1200175ノート

反応式

HRID 1200175 の反応式
[C:1]([O-])(=O)C.[Na+].C(OCOCC)C.P(Cl)(Cl)(Cl)=O.[CH3:18][C:19]1[C:36](=[O:37])[CH2:35][CH2:34][C@@:33]2([CH3:38])[C:20]=1[CH2:21][CH2:22][C@@H:23]1[C@@H:32]2[CH2:31][CH2:30][C@@:28]2([CH3:29])[C@H:24]1[CH2:25][CH2:26][C:27]2=[O:39].C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)(Cl)Cl>[CH3:18][C:19]1[C:36](=[O:37])[CH2:35][CH2:34][C@@:33]2([CH3:38])[C:20]=1[C:21](=[CH2:1])[CH2:22][C@@H:23]1[C@@H:32]2[CH2:31][CH2:30][C@@:28]2([CH3:29])[C@H:24]1[CH2:25][CH2:26][C:27]2=[O:39]

参加物

7

反応物 5

HCID 10024DiethoxymethaneHCID 10340Sodium CarbonateHCID 24813Phosphorus oxychlorideHCID 517045Sodium AcetateHCID 147309424-Methyl-4-androsten-3,17-dione

生成物 1

HCID 158591234-Methyl-6-methylenandrost-4-ene-3,17-dione収率 60%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Alternatively, a mixture of androst-4-ene-3,17-dione, thiophenol, 40% aqueous formaldehyde, triethylamine and ethanol was heated under reflux for a period of about 48 hours. The cooled solution was poured onto an aqueous sodium hydroxide solution and the product isolated by ether extraction. The ether extracts were washed with water and dried over magnesium sulfate. The resulting residue was triturated with hexane to remove any condensation by-product derived from the thiophenol and formaldehyde. The 4-phenylthiomethylandrost-4-ene-3,17-dione so obtained was desulfurized by dissolving in acetone and adding to a suspension of Raney Nickel in refluxing acetone. The mixture was refluxed for about 5 hours under stirring. The hot solution was filtered and the catalyst washed with boiling ethanol and water. The combined filtrates were concentrated under vacuum whereupon the product separated as a solid mass. Recrystallization from acetone/hexane yielded 4-methylandrost-4-ene-3,17-dione. A mixture of sodium acetate (1 g), absolute chloroform (30 ml), formaldehyde diethyl acetal (30 ml, 0.24 mol), phosphoryl chloride (3.8 ml, 0.04 mol), and 4-methylandrost-4-ene-3,17-dione (0.81 g, 2.7 mmol) was refluxed for about 7 hours, i.e. until the starting material has disappeared. The suspension was allowed to cool and under vigorous stirring a saturated sodium carbonate solution was added dropwise until the pH of the aqueous layer became alcaline (~1 hour). The organic layer was separated, neutralized with water, and dried over sodium sulfate. After concentration under reduced pressure the oily residue was purified by chromatography on silica gel using hexane/ethylacetate as eluent. Thus the pure 4-methyl-6-methylenandrost-4-ene-3,17-dione was obtained in 60% yield; I.R. (KBr): 3080 (6=CH2), 1735 (17-oxo), 1665 (3-oxo), 1635, 1595 cm-1 (Δ4 and 6=CH2).

後処理

  1. temperaturewas refluxed for about 7 hours
  2. temperatureto cool
  3. additionwas added dropwise until the pH of the aqueous layer
  4. custom(~1 hour)
  5. customThe organic layer was separated
  6. dry with materialdried over sodium sulfate
  7. concentrationAfter concentration under reduced pressure the oily residue
  8. customwas purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-04fe24507b2741358f7bb74dcdd61bc8
出典データセット
uspto-grants-1990_02
特許番号
US04904650

反応ノート

読み込み中…