反应详情

To a mixture of 310 mg (0.8 mmol) of 4-[(2-chloro-6-methylpyrimidin-4-yl)oxy]-2,5-dimethyl-aniline in 20 ml acetonitrile 208 mg (1.5 mmol) of N-(dimethoxymethyl)-N-methylethanamine (77% pure) was added. The reaction mixture was refluxed for 20 hrs. The reaction mixture was concentrated in vacuo, diluted with ethyl acetate and washed with water. The organic layer was dried over magnesium sulfate and concentrated in vacuo yielded 220 mg (59%) with a purity of 72% log P (pH=2.3)=1.45.

1. additionwas added
2. temperatureThe reaction mixture was refluxed for 20 hrs
3. concentrationThe reaction mixture was concentrated in vacuo
4. additiondiluted with ethyl acetate
5. washwashed with water
6. dry with materialThe organic layer was dried over magnesium sulfate
7. concentrationconcentrated in vacuo
8. customyielded 220 mg (59%) with a purity of 72% log P (pH=2.3)=1.45