反应详情

0.322 g (0.62 mmol) of the above prepared (2-methyl-4-{1-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethylsulfanyl}-phenoxy)-acetic acid tert-butyl ester, containing some methyl ester, was dissolved in 3.8 ml of THF/EtOH=1/1, treated with 1.87 ml (3 eq.) of 1N NaOH, and kept at ambient temperature for 2 h. The reaction mixture was then poured onto crashed ice/HCl dil., extracted twice with AcOEt, washed with water, dried over sodium sulfate, and evaporated to dryness to leave, after crystallization from AcOEt/hexane, 0.276 g of the title compound as off-white solid of mp. 115–117° C.

1. additionThe reaction mixture was then poured
2. extractionextracted twice with AcOEt
3. washwashed with water
4. dry with materialdried over sodium sulfate
5. customevaporated to dryness
6. customto leave
7. customafter crystallization from AcOEt/hexane, 0.276 g of the title compound as off-white solid of mp. 115–117° C.