反应详情

0.243 g (0.483 mmol) of the above prepared 2-methyl-2-{2-methyl-4-[2-methyl-6-(4-trifluoromethoxy-phenyl)-pyridin-3-ylmethoxy]-phenoxy}-propionic acid ethyl ester was dissolved in 2.9 ml of THF/EtOH=1/1, treated with 1.45 ml (3 eq.) of 1N NaOH and kept at room temperature for 4 h. The reaction mixture was then poured onto crashed ice/AcOEt/HCl dil., the aqueous phase extracted again with AcOEt; the combined organic layers were washed with water, dried over sodium sulfate, and evaporated to dryness. Recrystallisation from AcOEt/hexane produced finally 0.221 g of the title compound as white solid of mp. 149–151° C.

1. additionThe reaction mixture was then poured
2. extractionthe aqueous phase extracted again with AcOEt
3. washthe combined organic layers were washed with water
4. dry with materialdried over sodium sulfate
5. customevaporated to dryness
6. customRecrystallisation from AcOEt/hexane