反应详情

5.10 g (14.9 mmol) 2-(5-benzyloxy-2-formyl-phenoxy)-2-methyl-propionic acid ethyl ester (prepared from 4-benzyloxy-2-hydroxybenzaldehyde and ethyl-bromoisobutyrate in analogy to the procedure described in example 52A]) was dissolved in 100 ml of ethanol and hydrogenated with 1.0 g of Pd—C (5%), 2 bar H2, 25° C., for two hours. The reaction mixture was filtered (Celite), the filter cake was washed twice with EtOH and the filtrate was evaporated. The crude product was purified by flash chromatography (SiO2, heptane/EtOAc) to give 3.37 g of the title compound as light yellow oil.

1. filtrationThe reaction mixture was filtered (Celite)
2. washthe filter cake was washed twice with EtOH
3. customthe filtrate was evaporated
4. customThe crude product was purified by flash chromatography (SiO2, heptane/EtOAc)