反应详情

温度

0 °C

0.25 g (0.94 mmol) of [2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-methanol (example 1M]), 0.15 g (1.03 mmol) of phthalimide and 0.32 g (1.20 mmol) of triphenylphosphine were dissolved in 10 ml of THF. The stirred reaction mixture was cooled down to 0° C. and a solution of 0.27 g (1.15 mmol) of di-tert.-butyl azodicarboxylate in 2 ml of THF was added drop by drop. Then, the reaction was warmed up to ambient temperature. After 1 hour, the solvent was evaporated and the residue purified by crystallization from MeCl2 and n-heptane to give 0.32 g of the title compound as a colorless solid.

1. customThe stirred reaction mixture
2. temperatureThen, the reaction was warmed up to ambient temperature
3. customthe solvent was evaporated
4. customthe residue purified by crystallization from MeCl2 and n-heptane