反应详情

The experimental protocol used is the same as that described for the compound 1, with 1-[(5 methoxy-1H-indole-3-yl)methylcarbonyl]-4-(4-aminophenyl)-piperazine replacing the 3,5-bis-(1,1-dimethylethyl)-4-hydroxy-N-(4-aminophenyl)-benzamide. The expected product is isolated in the form of the free base with a yield of 20% (pale yellow powder). Melting point: 221-222° C. NMR 1H (400 MHz, DMSO d6, δ): 10.78 (s, 1 H, indolic NH); 7.72 (m, 1 H, thiophene); 7.59 (m, 1 H, thiophene); 7.22 (d, 1 H, indole, J=8.7 Hz); 7.19 (m, 1 H, thiophene); 7.09 (m, 2 H, indole); 6.82 (m, 4 H, Ph); 6.72 (m, 1 H indole); 6.35 (s, 2 H, NH2); 3.80 (s, 2 H, CH2); 3.73 (s, 3 H, CH3); 3.62 (m, 4 H, piperazine); 2.95 (m, 4 H, piperazine).