HCID 12153759, compound → HCID 57457959, compound

HRID 1245042Notes

Reaction equation

HRID 1245042 reaction equation
CO[C:3](=O)[C@@H:4]1[CH2:8][C:7](=[CH2:9])[CH2:6][N:5]1[C:10](OCC1C=CC=CC=1)=O.[CH2:21]([O:28]C(N1C2C(=CC=CC=2)CC1C(OC)=O)=O)[C:22]1C=CC=CC=1>>[CH2:9]=[C:7]1[CH2:6][N:5]2[C@H:4]([CH2:3][C:21](=[O:28])[CH2:22][CH2:10]2)[CH2:8]1

Participants

3

Reactant 2

HCID 12153759HCID 12153759, compoundHCID 54190049(S)-1-Benzyl 2-methyl 4-methylenepyrrolidine-1,2-dicarboxylate

Product 1

HCID 57457959HCID 57457959, compoundYield 61%

Procedure

In a similar manner to the procedures described in Preparative Examples 5(i)′ and 5(ii) above, reduction, methanesulfonylation and cyanogenation were conducted, using (S)-1-benzyloxycarbonyl-4-methylideneproline methyl ester [obtained as described in Preparative Example 8(i)′ above], instead of methyl 1-benzyloxycarbonylindoline-2-carboxylate, to give the title compound as a colorless oil (yield: 61%).

Workup

  1. customobtained

Sources & evidence

ORD record
ord-ff80bc77a3554abfbb9029d5b81ba0ee
Source dataset
uspto-grants-2006_10
Patent number
US07122666B2

Reaction notes

Loading…