反应详情

3-(1-Acetyl-1,4-dihydro-4-pyridyl)-5-methoxyindole (3.0 g) was dissolved in hot ethanol (150 ml) and hydrogenation was carried out with Adams catalyst (0.25 g). The mixture was filtered and the filtrate was concentrated under reduced pressure to give a residue containing 3-(1-acetyl-4-piperidyl)-5-methoxyindole. This residue was diluted with 2N aqueous sodium hydroxide solution (22 ml) and ethanol (30 ml) and refluxed for 18 hours. Ethanol was then distilled off and the residue was cooled. The precipitate was collected by filtration and recrystallized from a mixture of ethanol and water to give 5-methoxy-3-(4piperidyl)indole (1.92 g).

1. filtrationThe mixture was filtered
2. concentrationthe filtrate was concentrated under reduced pressure
3. customto give a residue
4. temperaturerefluxed for 18 hours
5. distillationEthanol was then distilled off
6. temperaturethe residue was cooled
7. filtrationThe precipitate was collected by filtration
8. customrecrystallized from a mixture of ethanol and water