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HRID1255787

反应详情

EQUATION

反应方程式

HRID 1255787 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)NC1=N[C@](C)(c2cccc([N+](=O)[O-])c2)CC(=O)N1Cc1ccccc1
HCID57496578

未命名化合物

结构：CC(C)(C)OC(=O)NC1=N[C@](C)(c2cccc(N)c2)CC(=O)N1Cc1ccccc1
HCID57501010

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NC1=N[C@](C)(c2cccc(N)c2)CC(=O)N1
HCID66644141

未命名化合物

收率 15.7%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O.CO
溶剂HCID21584119

未命名化合物

PROCEDURE

实验过程

Starting from [(S)-1-benzyl-4-methyl-4-(3-nitro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester (0.98 mmole), the crude material was chromatographed on silica using n-heptane/ethyl acetate (5:2) to give a first fraction containing [(S)-4-(3-amino-phenyl)-1-benzyl-4-methyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester (224 mg) as a colourless foam. MS (ESI): m/z=409.4 [ M+H]+ The second fraction was obtained using ethyl acetate/MeOH (9:1) to give [(S)-4-(3-amino-phenyl)-4-methyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester (49 mg) as a colourless oil. MS (ESI): m/z=319.3 [ M+H]+.

WORKUP

后处理

  1. customthe crude material was chromatographed on silica
  2. customto give a first fraction
  3. customMS (ESI): m/z=409.4 [ M+H]+ The second fraction was obtained