反应详情

4-Fluoro-2-methoxy-1-nitrobenzene (1.550 g, 9.06 mmol), 3,3-dimethylpiperidin-4-one (INTERMEDIATE 38) (2.17 g, 9.06 mmol, TFA salt), and potassium carbonate (2.504 g, 18.12 mmol) in DMF (20 ml) were heated at 70° C. overnight. The reaction mixture was concentrated in vacuo to remove the solvent. The residue was partitioned between CH2Cl2 (100 mL) and water (30 mL). The organic phase was dried over MgSO4 and concentrated in vacuo. The residue was purified using silica gel column (50%-100% CH2Cl2/Hexane) to obtain the title product (1.100 g, 43.6%).

1. concentrationThe reaction mixture was concentrated in vacuo
2. customto remove the solvent
3. customThe residue was partitioned between CH2Cl2 (100 mL) and water (30 mL)
4. dry with materialThe organic phase was dried over MgSO4
5. concentrationconcentrated in vacuo
6. customThe residue was purified