反应详情

To a solution of the compound (209 mg, 1.0 mmol) obtained in Example 178a in ethanol (4 ml) was added 2-bromo-1-(3,4-dichlorophenyl)ethanone (268 mg, 1.00 mmol), and the mixture was heated under reflux for 1.5 hr. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with diluted aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate. The extract was washed with saturated brine, dried over sodium sulfate, and concentrated under reduced pressure. The residue was purified by column chromatography (carrier: silica gel, eluent: hexane-ethyl acetate) to give the title compound (352 mg, 93%) as a yellow solid.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 1.5 hr
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. additionthe residue was diluted with diluted aqueous sodium hydrogen carbonate solution
5. extractionextracted with ethyl acetate
6. washThe extract was washed with saturated brine
7. dry with materialdried over sodium sulfate
8. concentrationconcentrated under reduced pressure
9. customThe residue was purified by column chromatography (carrier: silica gel, eluent: hexane-ethyl acetate)