反应详情

To a stirred solution of 6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridine-2-carbaldehyde (0.4 g, 1.24 mmol, 1 eq.) in 100 ml of dry THF, was added sodium triacetoxyborohydride (0.276 mmol, 1.3 mmol, 1.05 eq.) in one portion. The reaction was stirred for 20 hrs, before the addition of 1M aqueous NaOH (100 ml). The mixture was stirred for 15 mins before extraction with EtOAc. The organic phase was dried over MgSO4 and evaporated. The residue was purified by chromatography on silica gel to give {6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}methanol (0.2 g, 47% yield) as a colourless gum.

1. dry with materialThe organic phase was dried over MgSO4
2. customevaporated
3. customThe residue was purified by chromatography on silica gel