反应详情

温度

50 °C

A 5 L four necked flask equipped with a heating mantle, mechanical stirrer, thermocouple, gas inlet adapter and gas outlet adapter is charged with (2R)-2-{[2-(benzyloxy)-4-nitrophenoxy]methyl}oxirane (100.00 g, 0.33 mol), sodium bicarbonate (27.88 g, 0.33 mol), palladium (5% on carbon, 50% water, 15 g) and ethanol (2 L). The mixture is heated to 50° C. The stirring is stopped and the flask is flushed with hydrogen gas (3 L). Stirring is resumed and hydrogen gas is titrated into the solution [7.4 L (0.33 mol) over 130 min]. Heating is discontinued and nitrogen is bubbled through the solution for 20 min. Once the solution is cooled to 25° C., the mixture is filtered through a pad of celite and the filter cake is washed with ethanol (1 L). The resulting solution is concentrated by rotary evaporation removing 2.5 L of ethanol. The solution is transferred to a 5 L four necked flask equipped with a mechanical stirrer, thermocouple and an addition funnel. Water (750 mL) is slowly added to the stirred solution over 30 min, and the solution is stirred for 15 min at which point a precipitate forms. Additional water (1.5 L) is added over 60 min and the suspension is stirred for 48 h. The precipitate is collected by vacuum filtration, and then the filter cake is washed with water and suction dried. The title compound (49.01 g, 70%) is obtained as a tan powder. LCMS (Standard Method): 2.23 min, 212 (M+H)+. 1NMR (300 MHz, CDCl3) δ 7.81-7.76 (m, 2H), 6.96 (d, J=8.5 Hz, 1H), 4.42 (dd, J=2.1, 11.2 Hz, 1H), 4.32-4.18 (m, 2H), 3.98-3.85 (m, 2H), 2.03 (br s, 1H).

1. customthe flask is flushed with hydrogen gas (3 L)
2. customis titrated into the solution [7.4 L (0.33 mol) over 130 min]
3. temperatureHeating
4. customnitrogen is bubbled through the solution for 20 min
5. temperatureOnce the solution is cooled to 25° C.
6. filtrationthe mixture is filtered through a pad of celite
7. washthe filter cake is washed with ethanol (1 L)
8. concentrationThe resulting solution is concentrated by rotary evaporation
9. customremoving 2.5 L of ethanol
10. customequipped with a mechanical stirrer
11. additionWater (750 mL) is slowly added to the stirred solution over 30 min
12. stirringthe solution is stirred for 15 min at which point a precipitate forms
13. additionAdditional water (1.5 L) is added over 60 min
14. stirringthe suspension is stirred for 48 h
15. filtrationThe precipitate is collected by vacuum filtration
16. washthe filter cake is washed with water and suction
17. customdried