反应详情

A 250 mL round bottomed flask equipped with a magnetic stir bar is charged with solid 95% potassium t-butoxide (1.57 g, 13.5 mmol) and DMF (6.5 mL), and the suspension is stirred until all the solids are dissolved. A DMF (4.0 mL) solution containing N-benzyl-1-[(2S)-7-nitro-2,3-dihydro-1,4-benzodioxin-2-yl]methanamine (1.00 g, 3.3 mmol) and (4-chlorophenoxy)acetonitrile (1.12 g, 6.7 mmol) is added over 3 min. After 30 min, a 2 N aqueous solution of HCl is added until pH 1 is obtained (˜9 mL). The solution is transferred to a separatory funnel and extracted with toluene (2×10 mL) and discarded. The product-containing aqueous phase is adjusted to pH 10 by the addition of 10 N aqueous NaOH, and extracted with toluene (2×10 mL). The product-containing organic phases are combined and washed with water (15 mL) and then with brine (15 mL), and the volatiles are removed by evaporation to give the title compound (1.01 g, 88%) as a syrup. LCMS (Basic Method): 2.06 min, 340 (M+H)+. 1H NMR (300 MHz, DMSO-d6) δ 7.71 (d, J=9.1 Hz, 1H), 7.35-7.17 (m, 5H), 7.10 (d, J=9.1 Hz, 1H), 4.50-4.37 (m, 2H), 4.16 (dd, J=7.0, 11.4 Hz, 1H), 4.10 (s, 2H), 3.76 (s, 2H), 2.87-2.74 (m, 2H), NH not observed.

1. customA 250 mL round bottomed flask equipped with a magnetic stir bar
2. dissolutionare dissolved
3. additionis added over 3 min
4. customis obtained (˜9 mL)
5. customThe solution is transferred to a separatory funnel
6. extractionextracted with toluene (2×10 mL)
7. additionThe product-containing aqueous phase is adjusted to pH 10 by the addition of 10 N aqueous NaOH
8. extractionextracted with toluene (2×10 mL)
9. washwashed with water (15 mL)
10. customwith brine (15 mL), and the volatiles are removed by evaporation