反应详情

The tited compound was prepare in an analogous fashion to Example 103 replacing [5-Bromo-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine with [5-Bromo-7-(4-methanesulfonyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine to give [7-(4-Methanesulfonyl-phenyl)-5-vinyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine (45 mg, 63%). LCMS (E/I+) 489.21 (M+H). NMR 1H (DSMO-d6)-9.23 (s, 1H), 8.99 (s, 1H), 8.48 (d, 2H, J=8.44 Hz), 8.07 (d, 2H, J=8.56 Hz), 7.66 (d, 2H, J=9.01 Hz), 7.00-7.18 (m, 2H), 7.00 (d, 2H, J=8.88 Hz), 5.82 (d, 1H, J=16.95 Hz), 5.21 (d, 1H, J=12.21 Hz), 3.80 (s, 3H), 3.02 (t, 4H, J=4.60 Hz), 2.44 (t, 4H, J=4.72 Hz), 2.21 (s, 3H).