反应详情

The compound was prepared in an analogous fashion to Example 69 replacing 1-(4-Nitro-phenyl)-piperazine with 1-(3-Nitro-phenyl)-piperazine and 2-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine with 2-Methanesulfinyl-7-(4-methanesulfonyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazine to afford 44.32 mg of (S)-1-(4-{3-[7-(4-Methanesulfonyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-piperazin-1-yl)-propan-2-ol as a lyophilized powder. (M+H)=507.10. 1H NMR (400 MHz, DMSO, d6) δ 9.49 (s, 2H), 9.08 (s, 1H), 8.51 (d, 2H, J=8.56 Hz), 8.03 (d, 2H, J=8.60 Hz), 7.41 (m, 1H), 7.37 (d, 1H, J=4.81 Hz), 7.25 (m, 2H), 7.01 (d, 1H, J=4.84 Hz), 6.67 (d, 1H, J=6.64 Hz), 4.15 (m, 2H), 3.75 (m, 2H), 3.53 (m, 2H), 3.31 (s, 3H), 3.11 (m, 3H), 3.03 (m, 2H), 1.13 (d, 3H, J=6.12 Hz).