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HRID1262072

反应详情

EQUATION

反应方程式

HRID 1262072 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)OB(c2ccccc2NS(C)(=O)=O)OC1(C)C
HCID4356525

N-[2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanesulfonamide

C13H20BNO4S

结构：CSc1ncc2cc(C)c(Br)n2n1
HCID66711515

未命名化合物

PRODUCTS

生成物

1
结构：CSc1ncc2cc(C)c(-c3ccccc3NS(C)(=O)=O)n2n1
HCID66710834

未命名化合物

PROCEDURE

实验过程

N-[2-(6-Methyl-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-methanesulfonamide was prepared in an analogous fashion to Example 47a after: replacing 2-methoxybenzeneboronic acid with N-[2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl]-methanesulfonamide, and replacing 7-Bromo-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazine with 7-Bromo-6-methyl-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazine, to give after purification via normal phase chromatography (EtOAc/hexane as eluant) N-[2-(6-Methyl-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-methanesulfonamide as a yellow solid (0.12 g, 44%). LC/MS (E/I+) 349.04 (M+H).

WORKUP

后处理

  1. customto give
  2. customafter purification via normal phase chromatography (EtOAc/hexane as eluant) N-[2-(6-Methyl-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-methanesulfonamide as a yellow solid (0.12 g, 44%)