反应详情

Preparation of title compound. A solution of 2-methyl-5-benzofuranamine (32 mg, 0.22 mmol) and 3,3-bis(methylthio)-2-cyanoacrylamide (41 mg, 0.22 mmol) in ethanol (0.35 mL) was stirred at 80° C. After stirring for 5 h, a solution of 3-aminohexahydro-1-phenylmethyl-2H-azepin-2-one (74 mg, 0.29 mmol) in ethanol (0.74 mL) was added. After stirring at 80° C. for 2 days, the reaction was purified by column chromatography (silica, 1% methanol/dichloromethane) to afford the title compound (37 mg, 37% yield): MS (ESI, pos. ion spectrum) m/z 458; HPLC (method A) tR 4.13 min.

1. stirringAfter stirring at 80° C. for 2 days
2. customthe reaction was purified by column chromatography (silica, 1% methanol/dichloromethane)