反应详情

A solution of N-(4-chloro-3-methyl-5-isoxazolyl)-N-(methoxyethoxy-methyl)-2 -[3,4-(methylenedioxy)benzoyl]thieno[2,3-b]pyridine-3-sulfonamide (0.15 g, 0.26 mmoles) in methanol (5 ml) and 4N HCl (2 ml) was heated to reflux for 3 hours then cooled to ambient temperature and concentrated. The residue was diluted with EtOAc (50 ml) and washed with saturated NaCl (2×50 ml). The organic layer was dried (MgSO4), filtered and concentrated to collect 0.10 g (81 %) of the title compound as a foamy yellow solid, m.p. 75-90° C.

1. temperatureto reflux for 3 hours
2. concentrationconcentrated
3. additionThe residue was diluted with EtOAc (50 ml)
4. washwashed with saturated NaCl (2×50 ml)
5. dry with materialThe organic layer was dried (MgSO4)
6. filtrationfiltered
7. concentrationconcentrated
8. customto collect 0.10 g (81 %) of the title compound as a foamy yellow solid, m.p. 75-90° C.