HRID1265652

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：Cc1cc(-c2cccc(C(=O)CC(=O)OC(C)(C)C)c2)on1

HCID69592871

未命名化合物

反应SMILES：COCCN(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1Cl

HCID69687800

未命名化合物

PRODUCTS

产物

反应SMILES：COCCN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3cc(C)no3)c2)cc1Cl

HCID86586808

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from {2-amino-4-chloro-5-[(2-methoxy-ethyl)-methyl-amino]-phenyl}-carbamic acid tert.-butyl ester (Example J4) (165 mg, 0.5 mmol) and 3-[3-(3-methyl-isoxazol-5-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester (Example K4) (165 mg, 0.55 mmol) according to the general procedure M. Obtained as an amorphous yellow substance (207 mg).

WORKUP

后处理

customObtained as an amorphous yellow substance (207 mg)

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-aab6058000f54e6cb220cebd9dd60616
来源数据集: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06544985B2
来源说明: uspto-grants-2003_04

反应SMILES

[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH2:16][CH2:17][O:18][CH3:19])[CH3:15])[C:11]([Cl:20])=[CH:10][C:9]=1[NH2:21])([CH3:4])([CH3:3])[CH3:2].C([O:27][C:28](=O)[CH2:29][C:30]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([C:38]2[O:42][N:41]=[C:40]([CH3:43])[CH:39]=2)[CH:33]=1)=[O:31])(C)(C)C>>[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH2:16][CH2:17][O:18][CH3:19])[CH3:15])[C:11]([Cl:20])=[CH:10][C:9]=1[NH:21][C:28](=[O:27])[CH2:29][C:30]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([C:38]2[O:42][N:41]=[C:40]([CH3:43])[CH:39]=2)[CH:33]=1)=[O:31])([CH3:4])([CH3:2])[CH3:3]