Potassium Carbonate → HCID 44378002, Verbindung

HRID 1266117Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1266117
[CH:1]1[C:10]2[C@H:11]3[CH2:16][NH:15][CH2:14][CH2:13][C@H:12]3[N:8]3[C:9]=2[C:4]([CH2:5][CH2:6][CH2:7]3)=[CH:3][CH:2]=1.Cl[CH2:18][CH2:19][CH2:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[NH2:29])=[O:22].C([O-])([O-])=O.[K+].[K+]>>[CH:1]1[C:10]2[C@H:11]3[CH2:16][N:15]([CH2:18][CH2:19][CH2:20][C:21]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[NH2:29])=[O:22])[CH2:14][CH2:13][C@H:12]3[N:8]3[C:9]=2[C:4]([CH2:5][CH2:6][CH2:7]3)=[CH:3][CH:2]=1

Komponenten

4

Edukt 3

HCID 11430Potassium CarbonateHCID 110525851-(2-Aminophenyl)-4-chloro-1-butanoneHCID 69433998HCID 69433998, Verbindung

Produkt 1

HCID 44378002HCID 44378002, VerbindungAusbeute 42,6 %

Versuchsvorschrift

The title compound (0.080 g, 42%) was prepared by the general method of Example 402 from (7aR,11aS)-5,6,7a,8,9,10,11,11a-octahydro-4H-pyrido[3′,4′:4,5]pyrrolo[3,2,1-ij]quinoline (0.11 g, 0.50 mmol), 4-chloro-2′-aminobutyrophenone (0.20 g, 1.0 mmol), KI (catalytic) and K2CO3 (0.14 g, 1.0 mmol) after chromatographic purification as a white amorphous solid. The 1H NMR was identical to that of Example 404, 4-((7aS,11aR)-5,6,8,9,11,11a-hexahydro-4H-pyrido[3′,4′:4,5]pyrrolo[3,2,1-ij]quinolin-10(7aH)-yl)-1-(2-aminophenyl)-1-butanone

Aufarbeitung

  1. customafter chromatographic purification as a white amorphous solid

Quellen und Nachweise

ORD-Eintrag
ord-68653dce58cd491c8c14f3350109ebdb
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06548493B1

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