反应详情

Subsequently, to absolution of 2-(N,N-dimethylaminomethyl)-1-methylpyrrole (30.00 g, 217.5 mmol) obtained above in ethanol (220 ml) was added methyl iodide (16.2 ml, 260–2 mmol) with stirring under ice-cooling, and then the resulting mixture was stirred at room temperature for 2 hours. After stirring, ethyl acetate (220 ml) was added to the reaction mixture. The crystals precipitated were collected by filtration, washed with ethyl acetate and dried to afford (1-methylpyrrol-2-yl)methyl trimethylammonium iodide (55.34 g, yield: 91%).

1. temperaturecooling
2. stirringthe resulting mixture was stirred at room temperature for 2 hours
3. stirringAfter stirring
4. customThe crystals precipitated
5. filtrationwere collected by filtration
6. washwashed with ethyl acetate
7. customdried