反应详情

A 100 mL Parr bottle was charged with 30 mg of 10% palladium on carbon (50% water) and covered with 10 mL ethanol. 3-[3-(ethoxycarbonylmethyl-amino)-4-methyl-phenyl]-piperidine-1-carboxylic acid benzyl ester (152 mg, 0.37 mmol) was dissolved in 10 mL ethanol and added to the catalyst suspension. The reaction was hydrogenated at 45 psi for 2 h. The catalyst was filtered through a celite plug. The filter cake was washed with 30 mL ethanol and the filtrate concentrated under reduced pressure to yield 126 mg (100%) of (2-methyl-5-piperidin-3-yl-phenylamino)-acetic acid ethyl ester as a clear oil.

1. additionadded to the catalyst suspension
2. filtrationThe catalyst was filtered through a celite plug
3. washThe filter cake was washed with 30 mL ethanol
4. concentrationthe filtrate concentrated under reduced pressure