反应详情

To a solution of ethyl [4-({butyl[4′-(trifluoromethyl)-1,1′-biphenyl-3-yl]amino}methyl)-2-methylphenoxy]acetate (105 mg, 0.21 mmol) in methanol (4 mL) and tetrahydrofuran (4 mL), was added 2M NaOH (2 mL) aq. After stirring for 1 h at room temperature the solvent was removed in vacuo and the residue acidified with 2M HCl, before extraction into ethyl acetate (2×20 mL). The organic solution was dried (MgSO4) and the solvents removed in vacuo to afford the title compound as a pale yellow foam (90 mg).

1. customwas removed in vacuo
2. extractionthe residue acidified with 2M HCl, before extraction into ethyl acetate (2×20 mL)
3. dry with materialThe organic solution was dried (MgSO4)
4. customthe solvents removed in vacuo