反应详情

To a well stirred suspension of (0.05 mol) of lithium alumunium hydride in 100 ml of anhydrous tetrahydrofuran, (0.043 mole) of 1-(2-cyanophenyl)pyrrole were added by small portions. Then the mixture was maintained with stirring at room temperature for 18 hours. Addition of aqueous ethanol to destroy the excess lithium aluminium hydride, followed by filtration afforded a solution, which was then evaporated in vacuo. The residue was extracted with ethyl ether, the organic layer washed with water and dried over anhydrous sodium sulphate. Removal of the solvent under reduced pressure gave a crude product, which was purified by passing through an alumina column eluting with chloroform to give 1-(2-aminomethylphenyl)pyrrole.

1. additionwere added by small portions
2. temperatureThen the mixture was maintained
3. stirringwith stirring at room temperature for 18 hours
4. customto destroy the excess lithium aluminium hydride
5. filtrationfollowed by filtration
6. customafforded a solution, which
7. customwas then evaporated in vacuo
8. extractionThe residue was extracted with ethyl ether
9. washthe organic layer washed with water
10. dry with materialdried over anhydrous sodium sulphate
11. customRemoval of the solvent under reduced pressure
12. customgave a crude product, which
13. customwas purified
14. washeluting with chloroform