反应详情

Part B: Prepared in a similar fashion as described for Example 413 using 3,5-dichloro-1-[(1R)-1-cyclopropylpropyl]-2(1H)-pyrazinone and 5,7-dibromoindoline as the starting materials. mp 164–165° C.; 1H NMR (300 MHz, CDCl3): δ 7.42 (d, J=1.8 Hz, 1 H), 7.22 (d, J=1.5 Hz, 1 H), 6.96 (s, 1 H), 4.26 (t, J=8.1 Hz, 2 H), 3.99 (app. q, J=8.3 Hz, 1 H), 3.08 (t, J=7.9 Hz, 2 H), 1.94–1.69 (m, 2 H), 1.02–0.92 (m, 1 H), 0.87 (t, J=7.5 Hz, 3 H), 0.78–0.68 (m, 1 H), 0.50–0.39 (m, 2 H), 0.29–0.22 (m, 1 H); HRMS (ESI) calcd for C18H19N3OBr2Cl (M+H)+: 485.9583; found m/z 485.9592.

1. customPart B: Prepared in a similar fashion