反应详情

was prepared from coupling of (7-chloro-thieno[3,2-b]pyridin-2-yl)-(3-hydroxy-pyrrolidin-1-yl)-methanone (2b) with intermediate 63a following Method C. 1H NMR (300 MHz, CD3OD) δ 8.45 (d, 1H, J=5.47 Hz), 7.84 (d, 1H, J=17.33 Hz), 7.40 (d, 1H, J=8.48 Hz), 7.29 (d, 1H, J=2.26 Hz), 7.13–7.08 (m, 1H), 6.74 (d, 1H, J=5.46 Hz), 4.42 (bs, 1H), 4.03–3.90 (m, 2H), 3.74–3.58(m, 5H), 2.66 (s, 3H), 2.10–1.97(m, 2H). LCMS (ESI+) [M+H]/z Calc'd 446, found 446. Anal. (C21H20N3O4SCl.0.7CH2Cl2), C, H, N.