反应详情

A mixture of 5-(2-fluoro-6-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochloride (Prep 15, 667 mg, 2.59 mmol), and K2CO3 (358 mg, 2.59 mmol) in DMF (25 ml) was stirred 30 minutes at room temperature. Then 90% 3-Bromo-1,1dimethoxy-propane (432 μl, 2.85 mmol) was added in three portions during 3 days. Solvent was then removed under vacuum at 40° C. and the residue washed with ethyl acetate. The organic phase was dried (Na2SO4), filtered and evaporated. The crude was purified by flash chromatography eluting with DCM-MeOH—NH4OH (98-2-0.2) to give 291 mg of the title compound as a white solid (35% yield).

1. customSolvent was then removed under vacuum at 40° C.
2. washthe residue washed with ethyl acetate
3. dry with materialThe organic phase was dried (Na2SO4)
4. filtrationfiltered
5. customevaporated
6. customThe crude was purified by flash chromatography
7. washeluting with DCM-MeOH—NH4OH (98-2-0.2)