反应详情

温度

0 °C

To a solution of {2-[5-[2-(7-aza-bicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethylphenyl)-1H-indol-3-yl]-ethyl} carbamic acid tert-butyl ester (252 mg in 10 mL methylene chloride) at 0° C. was added 0.60 mL anisole followed by 3.7 mL trifluoroacetic acid and the mixture stirred at 0° C. After 1.5 hours, the mixture was concentrated in vacuo and the residual acid removed by azeotrope with toluene. Purifiaction by flash chromatography on silica gel (methylene chloride:methanol:ammonium hydroxide, 90:7:1) gave the title compound (196 mg).

1. concentrationthe mixture was concentrated in vacuo
2. customthe residual acid removed by azeotrope with toluene