反应详情

To 600 mg of ethyl 5-benzylamino-1-[3,5-difluoro-6-(p-methoxybenzylamino)pyridine-2-yl]-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate was added 2 ml of trifluoroacetic acid, and the mixture was allowed to stand at room temperature for 20 minutes. The solution was concentrated under reduced pressure, and 3 ml of ethanol was added to the residue, and the solution was again concentrated under reduced pressure. The precipitate was dispersed in ethanol, collected by filtration and washed with ethanol to obtain 530 mg of the title compound as a yellow powder.

1. concentrationThe solution was concentrated under reduced pressure, and 3 ml of ethanol
2. additionwas added to the residue
3. concentrationthe solution was again concentrated under reduced pressure
4. additionThe precipitate was dispersed in ethanol
5. filtrationcollected by filtration
6. washwashed with ethanol