反应详情

The procedure is the same as that described for compound 7a, except that cyclopropylamine was used instead of isopropylamine, and compound 4a (300 mg, 0.80 mmoles) was used. Yield 299 mg (65%) as a white solid. Mp: 184-186° C. 1H NMR (DMSO-d6): δ7.47 (s, 1H), 7.36 (s, 1H), 7.05 (bs, 1H, D2O exchangeable), 5.72 (m, 1H), 5.24 (m, 1H, D2O exchangeable), 5.17 (m, 1H, D2O exchangeable), 4.65 (bs, 2H, D2O exchangeable), 4.53 (m, 1H), 4.42 (m, 1H), 4.15 (m, 1H), 3.66 and 3.57 (m, 2H), 0.86 (m, 2H), 0.57 (m, 1H), 0.50 (m, 1H). Anal. (C15H17O4N3Cl2) C, H, N.