反应详情

51 g Nε-tert.butyloxycarbonyl-L-lysine were converted in a conventional manner into the benzyltriethylammonium salt and then stirred in 700 ml dimethylformamide with 81 g benzyloxycarbonyl-L-asparagine-4-nitrophenyl ester with the addition of 1 equivalent of pyridine for 48 hours at 20°. The residue left after vacuum evaporation was treated with ethyl acetate and potassium hydrogen sulfate solutions simultaneously; the thick precipitate formed was filtered off and then recrystallised from ethanol/petroleum ether. F = 174° - 175° (Z);[α]D20 = + 13.8° (c = 1.0; in pyridine). Yield = 70 g (71 % of the theoretical amount).

1. waitThe residue left
2. customafter vacuum evaporation
3. additionwas treated with ethyl acetate and potassium hydrogen sulfate solutions simultaneously
4. customthe thick precipitate formed
5. filtrationwas filtered off
6. customrecrystallised from ethanol/petroleum ether
7. customF = 174° - 175° (Z)
8. custom[α]D20 = + 13.8° (c = 1.0; in pyridine)