Cyclobenzaprine → HCID 21412096, compound

HRID 1284260Notes

Reaction equation

HRID 1284260 reaction equation
[CH3:1][N:2](C)[CH2:3][CH2:4][CH2:5][CH:6]1[C:12]2[CH:13]=[C:14]([S:17]([CH3:20])(=[O:19])=[O:18])[CH:15]=[CH:16][C:11]=2[CH:10]=[CH:9][C:8]2[CH:21]=[CH:22][CH:23]=[CH:24][C:7]1=2.CN(C)CCC=C1C2C=CC=CC=2C=CC2C=CC=CC1=2>>[CH3:1][NH:2][CH2:3][CH2:4][CH2:5][CH:6]1[C:12]2[CH:13]=[C:14]([S:17]([CH3:20])(=[O:18])=[O:19])[CH:15]=[CH:16][C:11]=2[CH:10]=[CH:9][C:8]2[CH:21]=[CH:22][CH:23]=[CH:24][C:7]1=2

Participants

3

Reactant 2

HCID 2895CyclobenzaprineHCID 21412098HCID 21412098, compound

Product 1

HCID 21412096HCID 21412096, compound

Procedure

By substituting 5-(3-dimethylaminopropyl)-3-methylsulfonyl-5H-dibenzo[a,d]cycloheptene for the 5-(3-dimethylaminopropylidene)-5H-dibenzo[a,d]cycloheptene of Example 6, Step A, and following substantially the same procedure described in Example 6, Steps A and B, there is obtained 5-(3-methylaminopropyl)-3-methylsulfonyl-5H-dibenzo[a,d]cycloheptene as an oily residue. The base is converted to the hydrogen oxalate salt by treating an ethanolic solution of the base with a 10% excess of oxalic acid in ethanol. Dilution with absolute ether precipitates 5-(3-methylaminopropyl)-3-methylsulfonyl-5H-dibenzo[a,d]-cycloheptene hydrogen oxalate as a white crystalline solid, m.p. 114°-119°C. dec. An analytical sample melts at 114°-115°C. dec. after two recrystallizations from mixtures of absolute ethanol and absolute ether.

Sources & evidence

ORD record
ord-67ffbcea93ad4b62b132efa084fd8f6b
Source dataset
uspto-grants-1976_08
Patent number
US03978121

Reaction notes

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