反应详情

5.6 g 2-amino-6-chloro-3-nitropyridine, 10 g 1-(3-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]-propyl)piperazine, 5 g potassium carbonate and 100 ml n-propanol are refluxed 21/2 hours. After cooling the precipitate is filtered off. The filtrate is concentrated to ca. 10 ml and diluted with the same volume of diisopropyl ether. The resulting cristallisate is admixed with the above mentioned precipitate and partitioned between water and methylene chloride. The organic phase is filtered and evaporated to give the heading compound, m.p. 117°-118°.

1. temperatureAfter cooling the precipitate
2. filtrationis filtered off
3. concentrationThe filtrate is concentrated to ca. 10 ml
4. additiondiluted with the same volume of diisopropyl ether
5. custompartitioned between water and methylene chloride
6. filtrationThe organic phase is filtered
7. customevaporated
8. customto give the heading compound, m.p. 117°-118°