反应详情

1.2 g (2.2 mmole) of the compound of Example 28 dissolved in 20 ml ethanol and 35 ml tetrahydrofuran was saponified with 0.3 g NaOH, the reaction mixture acidified with dilute HCl to pH 3 and extracted with ethyl acetate. The organic phase was washed with water until neutral, then with brine and dried with magnesium sulfate. The crude residue after evaporation of the solvent was triturated with benzene and 0.18 (16%) of the title compound as a white solid, mp 95.5°-97.5° C., separated by filtration. Calc: C, 67.68; H, 7.44; Found: C, 67.56; H, 7.34.

1. extractionextracted with ethyl acetate
2. washThe organic phase was washed with water until neutral, then with brine
3. dry with materialdried with magnesium sulfate
4. customThe crude residue after evaporation of the solvent
5. customwas triturated with benzene and 0.18 (16%) of the title compound as a white solid, mp 95.5°-97.5° C.
6. customseparated by filtration