反应详情

First, 5.3 g of 13-[trans-4-(2,3-difluorophenyl)cyclohexyl]tridecyl 2,2-bis(6-benzyloxyhexyl)acetate, 1.7 g of 10% Pd-C, and 100 ml of tetrahydrofuran were placed in a 300 ml autoclave. The mixture was stirred at room temperature for 2 days under a hydrogen pressure of 10 kg/cm2. A catalyst was filtered away and a filtrate was concentrated. Thereafter, the residue was purified by silica gel column chromatography (eluent: toluene/ethyl acetate=7/3) to obtain 4.1 g of 13-[trans-4-(2,3-difluorophenyl)cyclohexyl]tridecyl 2,2-bis(6-hydroxyhexyl)acetate (Y: 98%). The compound thus obtained had a purity of 99% by HPLC.

1. filtrationA catalyst was filtered away
2. concentrationa filtrate was concentrated
3. customThereafter, the residue was purified by silica gel column chromatography (eluent: toluene/ethyl acetate=7/3)