反应详情

A mixture of 2-amino-3-(2,6-dichlorobenzyloxy)-pyridine (1.345 g) and 3-bromo-1,1,1-trifluoroacetone (1.147 g) in ethanol (26 ml) was refluxed for 5 hours, cooled, and concentrated in vacuo. The residue was partitioned between ethyl acetate and aqueous sodium bicarbonate solution. The organic layer was washed with water, dried, and concentrated under reduced pressure to give a solid, which was purified by flash chromatography on silica gel to give 8-(2,6-dichlorobenzyloxy)-2-trifluoromethylimidazo[1,2-a]pyridine as a white solid (803 mg).

1. temperaturewas refluxed for 5 hours
2. temperaturecooled
3. concentrationconcentrated in vacuo
4. customThe residue was partitioned between ethyl acetate and aqueous sodium bicarbonate solution
5. washThe organic layer was washed with water
6. customdried
7. concentrationconcentrated under reduced pressure
8. customto give a solid, which
9. customwas purified by flash chromatography on silica gel