反应详情

Following the method of Example 155, but starting from 4-(4-hydroxymethylpiperidin-1-yl)pyridine and methyl 3-(4-hydroxyphenyl)propionate, the title compound was prepared in 14% yield: m.p. 96.5°-98.5° C.; NMR (d6DMSO) δ8.13(2H,d), 7.11(2H,d), 6.83(4H,m), 3.97(2H,dm), 3.81(2H,d), 3.56(3H,s), 2.87(2H,dt), 2.77(2H,t), 2.57(2H,t), 2.01(1H,m), 1.84(2H,m), 1.30(2H,m); m/e 355 (M+H)+ ; calculated for C21H26N2O3.0.75H2O: C, 68.5; H, 7.2; N, 7.8. found: C, 68.5; H, 7.5; N, 7.6%.