HRID1291026

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：N=C(NC(=O)OCc1ccccc1)c1ccc2oc(C(=O)O)cc2c1

HCID140381248

未命名化合物

结构：CCCCN(CC(=O)OC(C)(C)C)[C@H]1CC[C@H](N)CC1

HCID178449148

未命名化合物

PRODUCTS

生成物

结构：CCCCN(CC(=O)OC(C)(C)C)[C@H]1CC[C@H](NC(=O)c2cc3cc(C(=N)NC(=O)OCc4ccccc4)ccc3o2)CC1

HCID178449149

未命名化合物

收率 75.6%

PROCEDURE

实验过程

In the same manner as in Example 15 (3), 5-(benzyloxycarbonylamidino)-2-benzofurancarboxylic acid (785 mg, 2.32 mmol) and t-butyl trans-(4-aminocyclohexyl-N-n-butylamino)acetate (680 mg, 2.32 mmol) were condensed and purified by silica gel column chromatography (n-hexane/ethyl acetate=1/1-1/4) to give 1.06 g of t-butyl trans-[4-[[5-(benzyloxycarbonylamidino)-2-benzofuranyl)carbonylamino)cyclohexyl-N-n-butylamino]acetate as a colorless solid (75%).

WORKUP

后处理

customcondensed
custompurified by silica gel column chromatography (n-hexane/ethyl acetate=1/1-1/4)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2c963952bab046408ade4dc0a9a3dcc7
来源数据集: uspto-grants-1998_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05753670
来源说明: uspto-grants-1998_05

反应 SMILES

[CH2:1]([O:8][C:9]([NH:11][C:12]([C:14]1[CH:15]=[CH:16][C:17]2[O:21][C:20]([C:22]([OH:24])=O)=[CH:19][C:18]=2[CH:25]=1)=[NH:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:26][C@H:27]1[CH2:32][CH2:31][C@H:30]([N:33]([CH2:38][C:39]([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:40])[CH2:34][CH2:35][CH2:36][CH3:37])[CH2:29][CH2:28]1>>[CH2:1]([O:8][C:9]([NH:11][C:12]([C:14]1[CH:15]=[CH:16][C:17]2[O:21][C:20]([C:22]([NH:26][C@H:27]3[CH2:28][CH2:29][C@H:30]([N:33]([CH2:38][C:39]([O:41][C:42]([CH3:43])([CH3:45])[CH3:44])=[O:40])[CH2:34][CH2:35][CH2:36][CH3:37])[CH2:31][CH2:32]3)=[O:24])=[CH:19][C:18]=2[CH:25]=1)=[NH:13])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1